CSMSS Journal of Innovative Dentistry   is a Biannual electronic journal of CSMSS Dental College & Hospital publishing research papers in broad specialty areas of Dental  sciences that are deemed to be of practical value for the daily practice of medicine. It is a multispecialty journal. The journal tries to adhere to the guidelines of COPE. The journal is open access and freely accessible for all. The journal also does not charge any article submission, processing or publication fee.

We invite UG-PG students/ researchers/ faculty to submit their research work as original articles, short articles, review articles, qualitative research, case reports, case series or letters to the editor.

General Guidelines

Manuscripts addressing topics in any discipline of dental sciences that are deemed to be of practical value for the daily practice of dentistry will be considered for review by this journal. All contributions should be submitted, electronically to https://www.cjid.in/cjidupload/ Authors are requested to submit the text, tables and artwork in electronic form to this address.

Only previously unpublished work should be submitted. Material that has been partly presented or presented as an abstract elsewhere should be acknowledged in a note. All individuals who are listed as authors of a manuscript must have participated sufficiently in the conception and design of the work and analysis of data (if applicable) as well as in the writing of the manuscript. The authors must also believe the manuscript represents valid work and must have reviewed the final version of the manuscript and approved it for publication. Materials submitted to the journal must not be under consideration for publication elsewhere. Manuscripts should be in English and must conform to the journal format. Manuscripts that do not comply with the journal requirements may be returned without review by the editor. All manuscripts will be subjected to peer review and revision. Accepted articles will become the property of the Journal, and excerpts or parts may not be published elsewhere without written permission from both the editors and the publishers.

All manuscripts must be submitted online. Authors submitting for the first time will need to register and then submit their papers online. Manuscripts should not be submitted unless registration process is complete. If the editor/reviewer suggests/requests any changes in the manuscripts, it is the corresponding author’s responsibility to ensure that a revised version is resubmitted through the Journal site. Because the review process will be conducted in a blinded format, you will be asked to provide separate files for your title page (containing all of the author details and contact information) along with a blinded version of your paper containing no author details or identity revealing information. Please refrain from using end notes as references or automatic list numbering because these features are lost in conversion. Simply type the reference number in parentheses in the text and superscript it and type the reference list using Arabic numbers. The references should be in Vancouver style. Formatting such as Greek letters, italics, super and subscripts maybe used in the test as per need. The coding scheme for such elements must be consistent throughout.

Authors are responsible for applying for permission for both print and electronic rights for all borrowed materials and are responsible for paying any fees related to the applications of these permissions.check the “guidelines for authors” for more details

Requirments as per type of Article

Original article: Structured abstract (Introduction, material and methods, important results/observations, discussion including conclusions) maximum 250 words; Word limit 3000 (excluding abstract, title, tables, figures, references); Maximum four tables and maximum four figures; Maximum 40 references.

Short article: Unstructured abstract 200 words; Word limit 1500 (excluding abstract, title, tables, figures, references); Maximum two tables and maximum two figures; Maximum 20 references.

Systematic review/Meta-analysis: Structured abstract (Introduction, material and methods, important results/observations, discussion including conclusions) maximum 250 words; Word limit 3500 (excluding abstract, title, tables, figures, references); Maximum five tables and maximum five figures; Maximum 60 references.

Case study: No abstract; Word limit 750; Maximum one table and one figure; Maximum 10 references

Letter to editor: No abstract; Word limit 750; No table and no figure; Maximum five references. It should be related to some article published most recently.horship: All individuals who are listed as authors of a manuscript must have participated sufficiently in the conception and design of the work and analysis of data (if applicable) as well as in the writing of the manuscript. The authors must also believe that the manuscript represents valid work and must have reviewed the final version of the manuscript and approved it for publication

Manuscript Preparation

The manuscript, including references, tables and legends, should be typed double spaced with 1” (2.5 cm) margins throughout. The Times New Roman script with 12 font size should be used uniformly. The American English language must be used throughout. The plagiarism of any type will not be accepted. The article will be checked for plagiarism. In case of finding such plagiarism the article will be rejected and sole responsibility will lie with author. Unless otherwise indicated, these guidelines are in accordance with “Uniform Requirements for Manuscripts submitted to Medical & Dental Journals”.

Sequence for Submission

1. INITIAL FILE (Including covering letter, acknowledgements, funding, declaration of interest, copy right, letter of approval of institutional ethics committee)

COVERING LETTER

A covering letter must accompany all submitted manuscripts. The covering letter should provide the name, complete postal address, telephone number, electronic mail address of the corresponding author. Author must mention few important features of the article for consideration of publication of the article in covering letter. Acknowledgement of receipt of manuscripts by the Editorial office will be made via email only. The responsibility will lie solely with corresponding author. The authors should clearly state that the manuscript or parts of it have not and will not be submitted elsewhere for publication.

ACKNOWLEDGEMENTS

It must be part of covering letter. The work of persons who do not qualify for authorship may be acknowledged. The acknowledgment may be for official permission, statistical analysis, cooperation etc. It must have a declaration of interest signed by all authors.

FUNDING

It must be a part of covering letter. If the work has received full or part financial support it must be clearly mentioned. The name and address of funding agency and the reference number along with date should be mentioned.

DECLARATION OF INTEREST

Authors are expected to disclose any commercial associations that might pose a conflict of interest in connection with the submitted manuscript. All authors must disclose any financial and personal relationships with other people or organizations that could inappropriately influence (bias) their work. Examples of potential conflicts of interest include employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/ registrations, and grants or other funding. If there are no conflicts of interest then please state this: 'Conflicts of interest: none'. All authors must sign the Declaration of Interest

COPY RIGHT

All authors should sign the copy right form as per template.

 

LETTER OF APPROVAL OF INSTITUTIONAL ETHICS COMMITTEE

It is mandatory when human or animal studies are reported. In interventional trials registered number obtained/received from competent authority is required.

2. TITLE PAGE

The title page of the original copy of the manuscript must include the family name (surname), given name and middle name (father/husband) in that sequence, highest academic title(s), and current affiliation(s) of the authors. The full address and telephone/mobile number and email address of the corresponding author should be clearly mentioned separately. The name/names of institutions where the work is performed should be mentioned The Title should be concise and informative. Titles are often used in information-retrieval systems. Avoid abbreviations and formulae where possible. Please clearly indicate the given name(s) and family name(s) of each author and check that all names are accurately spelled. Present the authors' affiliation addresses (where the actual work was done) below the names. Indicate all affiliations with a lowercase superscript letter immediately after the author's name and in front of the appropriate address. Provide the full postal address of each affiliation, including the country name and, if available, the e-mail address of each author. Clearly indicate who will be the corresponding author and will handle correspondence at all stages of refereeing and publication and also post-publication. Ensure that the e-mail address is given and that contact details are kept up to date by the corresponding author. If an author has moved since the work described in the article was done, or was visiting at the time, a 'Present address' (or 'Permanent address') may be indicated as a footnote to that author's name. The address at which the author actually did the work must be retained as the main, affiliation address. Superscript Arabic numerals are used for such footnotes)

3. MAIN FILE (including abstract and key words, introduction, material and methods, results/observation, discussion, conclusions, references, tables and figures)

ABSTRACT

The abstract should be typed on a separate page and should not exceed 250 words. The abstract should state briefly the purpose of the research, the principal results and major conclusions. An abstract is often presented separately from the article, so it must be able to stand alone. For this reason, references should be avoided. Also, non-standard or uncommon abbreviations should be avoided, but if essential, they must be defined at their first mention in the abstract itself. Using American spelling and avoiding general and plural terms and multiple concepts (avoid, for example, 'and', 'of'). The abstract should be followed by a maximum of 6 key words. (These keywords will be used for indexing purposes.)

INTRODUCTION

It should start from general terms and then gradually describe the specific need and designing of the study. It should end at aims and specific objectives. It should be about 20% of total word limit of the article.

MATERIAL AND METHODS

There must be clear mention about type of study as observational or interventional. Study location/site, study period, participants and inclusion/exclusion criteria, sample size estimation and sampling method, personnel who actually collected data, tests/statistical operations used, operational definitions need to be mentioned. All studied variables must be mentioned. All the units of measurements should be internationally accepted. The details of material used may be mentioned with specifications. Author should write about exercised quality checks. The standard guidelines like STROBE, STARD, CONSORT, PRISMA should be followed for writing paper as per study design. The Materials and Methods section should not reveal an identity of the institution(s) where the work was performed.

RESULTS/OBSERVATIONS

The interventional studies should use term ‘results’ and observational studies should use term ‘observations’. Initial part of results/observations may the number of participants, demographic characteristics in brief. The statistical tests used should be mentioned. The actual P value should be written below the result/observation. If table is given, statistical test and P value should be included along with table.

DISCUSSION

It is expected that most of the discussion should revolve around your observations. Whenever sensitive or controversial or shocking/appalling statements are made, they should be supported by proper references. The author must substantiate the findings with appropriate reasons.

LIMITATIONS

CONCLUSIONS

RECOMMENDATIONS IF ANY

ACKNOWLEDGEMENTS

 

 

REFERENCES

Reference numbers in the text should follow numerical order and be enclosed in parentheses or superscripted. References are listed in the order in which they are referred in the text, not in alphabetical order. The reference style used by this journal is Vancouver numbered. The reference style used by this journal will be applied to the accepted article by the publisher at proof stage. Please ensure that every reference cited in the text is also present in the reference list (and vice versa). Unpublished results and personal communications are not recommended in the reference list, but may be mentioned in the text. If these references are included in the reference list they should follow the standard reference style of the journal and should include a substitution of the publication date with either 'Unpublished results' or 'Personal communication'. Citation of a reference as 'in press' implies that the item has been accepted for publication. Authors preferably refrain from quoting references more than 15 years old.

Increased discoverability of research and high quality peer review are ensured by online links to the sources cited. Hence data provided in the references should be correct. When copying references please be careful as they may already contain an error. In order to allow us to create links to abstracting and indexing services, such as Scopus, CrossRef and PubMed, please ensure that data provided in the references are correct. Please note that incorrect surnames, journal/book titles, publication year and pagination may prevent link creation. Use of the Digital Object Identifier services (DOI) is encouraged. A DOI can be used to cite and link to electronic articles where an article is in-press and full citation details are not yet known, but the article is available online. A DOI is guaranteed never to change, so you can use it as a permanent link to any electronic article. Please note the format of such citations should be in the same style as all other references in the paper.

Web References

The full URL should be given and the date when the reference was last accessed. Any further information, if known, (DOI, author names, dates, reference to a source publication, etc.) should also be given. Journal names should be abbreviated according to the List of Title Word Abbreviations. The complete web address should be given mentioning; (Available at :……………………………………) .Then the date of last access should be mentioned as; (Accessed on: 1st February 2018). For standard details authors are requested to refer; https://www.nlm.nih.gov/bsd/uniform_requirements.html.

 

 

 

 

4. TABLES

All tables must be numbered sequentially in Arabic numerals in the order of their citation in the text. Each table should be typed double-spaced on a separate sheet of paper and should be accompanied by a clear and specific title. Please submit tables as editable text and not as images. Tables should be placed on separate page(s) at the end. Number tables consecutively in accordance with their appearance in the text and place any table notes below the table body. Be sparing in the use of tables and ensure that the data presented in them do not duplicate results described elsewhere in the article. Please avoid using vertical rules and shading in table cells. The table number and title should be at the top and centrally placed. The title should be self explanatory. (E.g. Table 5: MEDICAL EMERGENCIES IN THE  DENTAL PRACTICE). The title should be in bold. The table should not have vertical lines.

5. FIGURES AND FIGURE LEGENDS

Figures must be submitted in electronic format. Images should be provided in JPG (JPEG) or PNG format. Graphics software such as Photoshop and Illustrator and not presentation software such as Power Point may be used to create art. Color images must be CMYK, at least 300 DPI, with a digital color proof and not a color laser print or color photography. Please include hardware and software information in addition to file names. For electronic artwork, make sure you use uniform lettering and sizing of your original artwork. Use only Times New Roman font of 12 size throughout. The title may be of higher font. Number the illustrations according to their sequence in the text. Use a logical naming convention for your artwork files. Provide captions to illustrations separately. Size the illustrations close to the desired dimensions of the published version as given below. Submit each illustration as a separate file. If your electronic artwork is created in a Microsoft Office application (Word, PowerPoint, Excel) then please supply 'as is' in the native document format. Regardless of the application used other than Microsoft Office, when your electronic artwork is finalized, please 'Save as' or convert the images to one of the following formats (note the resolution requirements for line drawings, halftones, and line/halftone combinations given below):

PNG/JPEG: Color or grayscale photographs (halftones); keep to a minimum of 300 dpi.

PNG/JPEG: Bitmapped (pure black & white pixels) line drawings, keep to a minimum of 1000 dpi.

PNG/JPEG: Combinations bitmapped line/half-tone (color or grayscale), keep to a minimum of 500 dpi.

 

Please do not supply files that are optimized for screen use (e.g., GIF, BMP, PICT, WPG); these typically have a low number of pixels and limited set of colors. Do not supply files that are too low in resolution or submit graphics that are disproportionately large for the content. All the figures must be of standard size as given below for inclusion in the print version.

Maximum size for portrait type of figure should be 8.5 cm (320 pixels) in width and 22.0 cm (831 pixels) in height. Landscape type of figure should be maximum 17.5 cm (661 pixels) in width and 10.0 cm (378 pixels) in height.

Any alteration in authorship after submission must be approved by all authors. This applies to additions, deletions, changes in authorship order or in attributed contributions, and such alterations must be explained to the journal. Authors may be contacted to ascertain whether they have agreed to any alteration.

Authors contribution:Each author’s contribution should be clearly mentioned in terms of conceptualization, design, data collection, implementation, data analysis, interpretation, and manuscript writing. All authors should have reviewed and approved the final version of manuscript.

Data availability statementA statement on data availability has to be included before the references. Authors may use following statement:

Data is available in public domain OR Request of data may be made to the corresponding author

AI disclosure: Mention whether AI was used in manuscript preparation. If used,

• Disclose and describe the contribution of AI in writing the manuscript.
• All authors should accept full responsibility for the contents of the manuscript and its supplementary material (text/ tables/ figures).

Copyright and declaration form: Corresponding authors should submit the scanned copy of copyright and declaration form with signature of all authors.

Permission: For content taken from any form of copyrighted material, such as direct quotations, figures or tables, authors must have obtained written releases from the copyright owner for its use, and would be responsible for any permission fees incurred. The original source must also be acknowledged in the submitted manuscript.

Ethical considerations: Our journal adheres to the ethical principles outlined by the Committee on Publication Ethics (COPE) available at: http://publicationethics.org/.

Research that involves human participants also includes studies that use only human blood, tissue, or medical records. Authors should confirm review of the study by an appropriate institutional review board or affirm that the research was conducted according to the principles of the Declaration of Helsinki (https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/). Manuscripts involving experimental investigations on human should include a statement that the research protocol was approved by relevant institutional review boards or ethics committees and that all human participants gave written informed consent.

For studies among participants involving vulnerable group (eg. children, pregnant women, sex workers, tribal population, sub-ordinate workers, prisoners etc.), additional safeguard measures should be executed and reported as per the CCRAS guidelines. For studies among children in 0-6 years age group, written informed consent of the parents or the legal authorized representative (LAR) should be taken and reported. For studies among children in 7-18 years age group, assent of the child along with the written informed consent of the parents or LAR should be taken and reported. Oral informed assent for children in 7-11 years age group and written informed assent among children in12-18 years age group should be taken and reported.

If authors did not obtain institutional review board approval before the start of the study, they should state and explain the circumstances. If the study was exempted from review, authors should state that such exemption complied with the policy of their local institutional review board.

For animal subjects, animal care and licensing guidelines under which the investigation was performed must be reported in accordance with the Animals in Research: Reporting In Vivo Experiments (ARRIVE) statement.

Withdrawal of an article: The author can send a request email and withdraw the article at any point of time, before publication.

Electronic submission: Manuscripts addressing topics in any discipline of Dental  sciences that are deemed to be of practical value for the daily practice of medicine will be considered for review by this journal. All contributions should be submitted, electronically to https://.in/upload/ Authors are requested to submit the text including tables and artwork in electronic form to this address.

Please note that the journal reserves the right to make modifications in the language, grammar, presentation, etc. to fit the journal’s requirements.

Type of Article

·         Original article

·         Short article

·         Case report

·         Letter to editor

·         Systematic review

·         Meta-analysis

·         Editorial (on request from Chief Editor)

Broad Specialities

·         Prosthodontics

·         Pediatric dentistry

·         Endodontics & conservative dentistry

·         Periodontics

·         Oral Medicine

·         Oral & Maxillofacial Surgery

·         Oral & Maxillofacial Radiology

·         Oral & Maxillofacial Pathology

·         Dental Public Health

·         Orthodontics and Dentofacial orthopedics

·         Laser Dentistry

·         Sports Dentistry

·         Dental Anesthesiology

·         Oral Biology

·         Forensic Odontology

Author References.

A.) Articles in Journals

1. Standard journal article

Halpern SD, Ubel PA, Caplan AL. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002 Jul 25;347(4):284-7.

List the first six authors, followed by et al. If there are more than six authors, list the first six authors, followed by et al. (Note: NLM now lists all authors.):

Rose ME, Huerbin MB, Melick J, Marion DW, Palmer AM, Schiding JK, et al. Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury. Brain Res. 2002;935(1-2):40-6.

Optional: If a journal carries continuous pagination throughout a volume (as many medical journals do), omit the month and issue number.

Halpern SD, Ubel PA, Caplan AL. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002;347:284-7.

Optional: Addition of a database's unique identifiers, such as the PubMed PMID, for the citation:

Forooghian F, Yeh S, Faia LJ, Nussenblatt RB. Uveitic foveal atrophy: clinical features and associations. Arch Ophthalmol. 2009 Feb;127(2):179-86. PubMed PMID: 19204236; PubMed Central PMCID: PMC2653214.

Optional: Addition of a clinical trial registration number:

Trachtenberg F, Maserejian NN, Soncini JA, Hayes C, Tavares M. Does fluoride in compomers prevent future caries in children? J Dent Res. 2009 Mar;88(3):276-9. PubMed PMID: 19329464. ClinicalTrials.gov registration number: NCT00065988.

2. Organization as author

Diabetes Prevention Program Research Group. Hypertension, insulin, and proinsulin in participants with impaired glucose tolerance. Hypertension. 2002;40(5):679-86.

3. Both personal authors and organization as author (List all as they appear in the byline.)

Vallancien G, Emberton M, Harving N, van Moorselaar RJ; Alf-One Study Group. Sexual dysfunction in 1,274 European men suffering from lower urinary tract symptoms. J Urol. 2003;169(6):2257-61.

4. No author given

21st century heart solution may have a sting in the tail. BMJ. 2002;325(7357):184.

5. Article not in English

Ellingsen AE, Wilhelmsen I. Sykdomsangst blant medisin- og jusstudenter. Tidsskr Nor Laegeforen. 2002;122(8):785-7. Norwegian.

Optional: Translation of article title (MEDLINE/PubMed practice):

Ellingsen AE, Wilhelmsen I. [Disease anxiety among medical students and law students]. Tidsskr Nor Laegeforen. 2002 Mar 20;122(8):785-7. Norwegian.

6. Volume with supplement

Geraud G, Spierings EL, Keywood C. Tolerability and safety of frovatriptan with short- and long-term use for treatment of migraine and in comparison with sumatriptan. Headache. 2002;42 Suppl 2:S93-9.

7. Issue with supplement

Glauser TA. Integrating clinical trial data into clinical practice. Neurology. 2002;58(12 Suppl 7):S6-12.

8. Volume with part

Abend SM, Kulish N. The psychoanalytic method from an epistemological viewpoint. Int J Psychoanal. 2002;83(Pt 2):491-5.

9. Issue with part

Ahrar K, Madoff DC, Gupta S, Wallace MJ, Price RE, Wright KC. Development of a large animal model for lung tumors. J Vasc Interv Radiol. 2002;13(9 Pt 1):923-8.

10. Issue with no volume

Banit DM, Kaufer H, Hartford JM. Intraoperative frozen section analysis in revision total joint arthroplasty. Clin Orthop. 2002;(401):230-8.

11. No volume or issue

Outreach: bringing HIV-positive individuals into care. HRSA Careaction. 2002 Jun:1-6.

12. Pagination in roman numerals

Chadwick R, Schuklenk U. The politics of ethical consensus finding. Bioethics. 2002;16(2):iii-v.

13. Type of article indicated as needed

Tor M, Turker H. International approaches to the prescription of long-term oxygen therapy [letter]. Eur Respir J. 2002;20(1):242.

Lofwall MR, Strain EC, Brooner RK, Kindbom KA, Bigelow GE. Characteristics of older methadone maintenance (MM) patients [abstract]. Drug Alcohol Depend. 2002;66 Suppl 1:S105.

14. Article containing retraction

Feifel D, Moutier CY, Perry W. Safety and tolerability of a rapidly escalating dose-loading regimen for risperidone. J Clin Psychiatry. 2002;63(2):169. Retraction of: Feifel D, Moutier CY, Perry W. J Clin Psychiatry. 2000;61(12):909-11.

Article containing a partial retraction:

Starkman JS, Wolder CE, Gomelsky A, Scarpero HM, Dmochowski RR. Voiding dysfunction after removal of eroded slings. J Urol. 2006 Dec;176(6 Pt 1):2749. Partial retraction of: Starkman JS, Wolter C, Gomelsky A, Scarpero HM, Dmochowski RR. J Urol. 2006 Sep;176(3):1040-4.

15. Article retracted

Feifel D, Moutier CY, Perry W. Safety and tolerability of a rapidly escalating dose-loading regimen for risperidone. J Clin Psychiatry. 2000;61(12):909-11. Retraction in: Feifel D, Moutier CY, Perry W. J Clin Psychiatry. 2002;63(2):169.

Article partially retracted:

Starkman JS, Wolter C, Gomelsky A, Scarpero HM, Dmochowski RR. Voiding dysfunction following removal of eroded synthetic mid urethral slings. J Urol. 2006 Sep;176(3):1040-4. Partial retraction in: Starkman JS, Wolder CE, Gomelsky A, Scarpero HM, Dmochowski RR. J Urol. 2006 Dec;176(6 Pt 1):2749.

16. Article republished with corrections

Mansharamani M, Chilton BS. The reproductive importance of P-type ATPases. Mol Cell Endocrinol. 2002;188(1-2):22-5. Corrected and republished from: Mol Cell Endocrinol. 2001;183(1-2):123-6.

17. Article with published erratum

Malinowski JM, Bolesta S. Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review. Clin Ther. 2000;22(10):1151-68; discussion 1149-50. Erratum in: Clin Ther. 2001;23(2):309.

18. Article published electronically ahead of the print version

Yu WM, Hawley TS, Hawley RG, Qu CK. Immortalization of yolk sac-derived precursor cells. Blood. 2002 Nov 15;100(10):3828-31. Epub 2002 Jul 5.

 

 

B.) Electronic Material

1.) Datasets

Dataset description article:

Kraemer MU, Sinka ME, Duda KA, Mylne A, Shearer FM, Brady OJ, Messina JP, Barker CM, Moore CG, Carvalho RG, Coelho GE, Van Bortel W, Hendrickx G, Schaffner F, Wint GR, Elyazar IR, Teng HJ, Hay SI.  The global compendium of Aedes aegypti and Ae. albopictus occurrence. Sci Data. 2015 Jul 7 [cited 2015 Oct 23];2:150035. Available from: http://www.nature.com/articles/sdata201535 doi: 10.1038/sdata.2015.35 eCollection 2015. PubMed PMID: 26175912; PubMed Central PMCID: PMC4493829.

Dataset deposit record: Citing Medicine format

Kraemer MUG, Sinka ME, Duda KA, Mylne A, Shearer FM, Brady OJ, Messina JP, Barker CM, Moore CG, Carvalho RG, Coelho GE, Van Bortel W, Hendrickx G, Schaffner F, Wint GRW, Elyazar IRF, Teng H, Hay SI. The global compendium of Aedes aegypti and Ae. albopictus occurrence [dataset]. 2015 Jun 30 [cited 2015 Oct 23]. In: Dryad Digital Repository [Internet]. Durham (NC): Dryad. 2008 Jan - . 3 files: 3.406 MB; 1.549 MB; 1.815 MB. Available from: https://datadryad.org/resource/doi:10.5061/dryad.47v3c Referenced in doi: 10.7554/eLife.08347